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抗Cav1.2(CACNA1C)抗体 | Alomone Labs ACC-003 产品信息
出版应用/物种/样本/稀释参考文献免疫印迹; 小鼠; 1:200; 图2dDai W, Laforest B, Tyan L, Shen K, Nadadur R, Alvarado F, et al. A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. elife. 2019;8: pubmed出版商 免疫印迹; 小鼠; 图2bHu J, Gao C, Wei C, Xue Y, Shao C, Hao Y, et al. RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure. Proc Natl Acad Sci U S A. 2019;116:6172-6180 pubmed出版商 免疫印迹; 小鼠; 图1bGuo A, Wang Y, Chen B, Wang Y, Yuan J, Zhang L, et al. E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. Science. 2018;362: pubmed出版商 免疫细胞化学; 人类; 1:100; 图4a免疫印迹; 人类; 1:1000; 图7aHu Z, Wang J, Yu D, Soon J, de Kleijn D, Foo R, et al. Aberrant Splicing Promotes Proteasomal Degradation of L-type CaV1.2 Calcium Channels by Competitive Binding for CaV???? Subunits in Cardiac Hypertrophy. Sci Rep. 2016;6:35247 pubmed出版商 免疫印迹; 人类; 1:500; 图2cHelms A, Alvarado F, Yob J, Tang V, Pagani F, Russell M, et al. Genotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy. Circulation. 2016;134:1738-1748 pubmed 免疫组化-石蜡切片; 豚鼠; 1:50; 图6Reyes García J, Flores Soto E, Solís Chagoyán H, Sommer B, Díaz Hernández V, García Hernández L, et al. Tumor Necrosis Factor Alpha Inhibits L-Type Ca(2+) Channels in Sensitized Guinea Pig Airway Smooth Muscle through ERK 1/2 Pathway. Mediators Inflamm. 2016;2016:5972302 pubmed出版商 Li Q, Zhu Z, Lu J, Chao Y, Zhou X, Huang Y, et al. Sleep deprivation of rats increases postsurgical expression and activity of L-type calcium channel in the dorsal root ganglion and slows recovery from postsurgical pain. Acta Neuropathol Commun. 2019;7:217 pubmed出版商 Atsuta Y, Tomizawa R, Levin M, Tabin C. L-type voltage-gated Ca2+ channel CaV1.2 regulates chondrogenesis during limb development. Proc Natl Acad Sci U S A. 2019;116:21592-21601 pubmed出版商 Arrojo e Drigo R, Jacob S, García Prieto C, Zheng X, Fukuda M, Nhu H, et al. Structural basis for delta cell paracrine regulation in pancreatic islets. Nat Commun. 2019;10:3700 pubmed出版商 Morgenstern T, Park J, Fan Q, Colecraft H. A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary CaVβ subunits. elife. 2019;8: pubmed出版商 Fei D, Zhang Y, Wu J, Zhang H, Liu A, He X, et al. Cav 1.2 regulates osteogenesis of bone marrow-derived mesenchymal stem cells via canonical Wnt pathway in age-related osteoporosis. Aging Cell. 2019;18:e12967 pubmed出版商 Lai Y, Zhu B, Sun F, Luo D, Ma Y, Luo B, et al. Estrogen receptor α promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP/PS1 mice. Aging Cell. 2019;18:e12961 pubmed出版商 Liang D, Wu Y, Zhou L, Chen Y, Liu H, Xie D, et al. LRP5 controls cardiac QT interval by modulating the metabolic homeostasis of L-type calcium channel. Int J Cardiol. 2019;275:120-128 pubmed出版商 Brandenburg S, Pawlowitz J, Fakuade F, Kownatzki Danger D, Kohl T, Mitronova G, et al. Axial Tubule Junctions Activate Atrial Ca2+ Release Across Species. Front Physiol. 2018;9:1227 pubmed出版商 Kamijo S, Ishii Y, Horigane S, Suzuki K, Ohkura M, Nakai J, et al. A Critical Neurodevelopmental Role for L-Type Voltage-Gated Calcium Channels in Neurite Extension and Radial Migration. J Neurosci. 2018;38:5551-5566 pubmed出版商 Kisko T, Braun M, Michels S, Witt S, Rietschel M, Culmsee C, et al. Cacna1c haploinsufficiency leads to pro-social 50-kHz ultrasonic communication deficits in rats. Dis Model Mech. 2018;11: pubmed出版商 Sahu G, Asmara H, Zhang F, Zamponi G, Turner R. Activity-Dependent Facilitation of CaV1.3 Calcium Channels Promotes KCa3.1 Activation in Hippocampal Neurons. J Neurosci. 2017;37:11255-11270 pubmed出版商 Hermosilla T, Encina M, Morales D, Moreno C, Conejeros C, Alfaro Valdés H, et al. Prolonged AT1R activation induces CaV1.2 channel internalization in rat cardiomyocytes. Sci Rep. 2017;7:10131 pubmed出版商 Papp R, Bett G, Lis A, Rasmusson R, Baczkó I, Varro A, et al. Genomic upregulation of cardiac Cav1.2? and NCX1 by estrogen in women. Biol Sex Differ. 2017;8:26 pubmed出版商 Buonarati O, Henderson P, Murphy G, Horne M, Hell J. Proteolytic processing of the L-type Ca 2+??channel alpha 11.2 subunit in neurons. F1000Res. 2017;6:1166 pubmed出版商 Feridooni H, Kane A, Ayaz O, Boroumandi A, Polidovitch N, Tsushima R, et al. The impact of age and frailty on ventricular structure and function in C57BL/6J mice. J Physiol. 2017;595:3721-3742 pubmed出版商 Varodayan F, de Guglielmo G, Logrip M, George O, Roberto M. Alcohol Dependence Disrupts Amygdalar L-Type Voltage-Gated Calcium Channel Mechanisms. J Neurosci. 2017;37:4593-4603 pubmed出版商 Oz S, Pankonien I, Belkacemi A, Flockerzi V, Klussmann E, Haase H, et al. Protein kinase A regulates C-terminally truncated CaV 1.2 in Xenopus oocytes: roles of N- and C-termini of the ?1C subunit. J Physiol. 2017;595:3181-3202 pubmed出版商 Jeong M, Kim H, Pyun J, Choi K, Lee D, Solhjoo S, et al. Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/????-catenin signaling. Proc Natl Acad Sci U S A. 2017;114:E1345-E1354 pubmed出版商 Cheli V, Santiago González D, Namgyal Lama T, Spreuer V, Handley V, Murphy G, et al. Conditional Deletion of the L-Type Calcium Channel Cav1.2 in Oligodendrocyte Progenitor Cells Affects Postnatal Myelination in Mice. J Neurosci. 2016;36:10853-10869 pubmed Philippart F, Destreel G, Merino Sepúlveda P, Henny P, Engel D, Seutin V. Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons. J Neurosci. 2016;36:7234-45 pubmed出版商 Cheli V, Santiago González D, Smith J, Spreuer V, Murphy G, Paez P. L-type voltage-operated calcium channels contribute to astrocyte activation In vitro. Glia. 2016;64:1396-415 pubmed出版商 Morishima M, Iwata E, Nakada C, Tsukamoto Y, Takanari H, Miyamoto S, et al. Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K(+) Channel, IK.ACh. Circ J. 2016;80:1346-55 pubmed出版商 Willis B, Pandit S, Ponce Balbuena D, Zarzoso M, Guerrero Serna G, Limbu B, et al. Constitutive Intracellular Na+ Excess in Purkinje Cells Promotes Arrhythmogenesis at Lower Levels of Stress Than Ventricular Myocytes From Mice With Catecholaminergic Polymorphic Ventricular Tachycardia. Circulation. 2016;133:2348-59 pubmed出版商 Forostyak O, Butenko O, Anderova M, Forostyak S, Sykova E, Verkhratsky A, et al. Specific profiles of ion channels and ionotropic receptors define adipose- and bone marrow derived stromal cells. Stem Cell Res. 2016;16:622-34 pubmed出版商 Schilling J, Horikawa Y, Zemljic Harpf A, Vincent K, Tyan L, Yu J, et al. Electrophysiology and metabolism of caveolin-3-overexpressing mice. Basic Res Cardiol. 2016;111:28 pubmed出版商 Lu Y, Chen Y, Kao Y, Lin Y, Yeh Y, Chen S, et al. Colchicine modulates calcium homeostasis and electrical property of HL-1 cells. J Cell Mol Med. 2016;20:1182-90 pubmed出版商 Fu Y, Shaw S, Naami R, Vuong C, Basheer W, Guo X, et al. Isoproterenol Promotes Rapid Ryanodine Receptor Movement to Bridging Integrator 1 (BIN1)-Organized Dyads. Circulation. 2016;133:388-97 pubmed出版商 Walton R, Jones S, Rostron K, Kayani A, Close G, McArdle A, et al. Interactions of Short-Term and Chronic Treadmill Training With Aging of the Left Ventricle of the Heart. J Gerontol A Biol Sci Med Sci. 2016;71:1005-13 pubmed出版商 图像 1: Peptide (C)TTKINMDDLQPSENEDKS corresponding to amino acid residues 848-865 of rat CaV1.2 (AccessionP22002). Intracellular loop between domains II and III.图像 2: Peptide (C)TTKINMDDLQPSENEDKS corresponding to amino acidresidues 848-865 of rat CaV1.2 (AccessionP22002). Intracellular loop between domains II and III.同源: Mouse - identical; guinea pig -17/18 amino acid residues identical; human, rabbit - 16/18 amino acid residues identical.同义词: CaV1.2, Voltage-dependent L-type Ca2+ channel subunit alpha1C,??Cacna1c交叉活性: 人类, 小鼠, 大鼠应用: Immunocytochemistry, Immunofluorescence, Indirect Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot抗体类型: 宿主: 共轭标签/标签/标记: SwissProt号: P22002浓度: 0.8毫克/毫升格式: Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.缓冲液: 磷酸盐缓冲液(PBS), pH值7.4防腐剂: 1% BSA, 0.05% NaN3包装: 储存: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.纯度: Affinity purified on immobilized antigen.抗体亚型: 免疫原: 克隆性: 区域/地区/末端: Intracellular loop between domains II and III免疫原序列: (C)TTKINMDDLQPSENEDKS, corresponding to amino acid??residues 848-865 of rat CaV1.2类别: Ion Channels, voltage-gated calcium channels研究领域(s): Cardiac, Heart, Neurodegenerative diseases, Alzheimer\'s disease, Neuroscience, Taste, Gustatory System, Auditory, Auditory System, Hearing, Sensory System, Cancer, tumor, tumour, Cardiovascular, Hypertension, Pulmonary Hypertension, Vascular Hypertension, Neurological Diseases, Addiction, Reward, Depression更多信息或购买: Alomone Labs 蚂蚁淘页Alomone LabsJerusalem BioPark (JBP), Hadassah Ein KeremP.O. Box 4287Jerusalem 9104201info@alomone.comhttp://www.alomone.com972-2-587-2202公司总部: 以色列Alomone Labs公司成立于1989年,在离子通道、GPCR及神经信号通路研究等领域占据全球领先地位。
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