Alomone-配体门控离子通道
—致力于离子通道产品研发20多年的离子通道专家
GABA(A)
受体 GABA(A)受体是离子转运γ-氨基丁酸A型受体。大多数的脑组织中快速抑制突触传导受这些配体门控离子通道的调节,到现在为止,在哺乳动物中枢神经系统中已克隆出19个GABA(A)受体,根据他们的序列又分成7个不同的亚类(α, β, γ, δ, ε, π和θ)。他们包含五个不同的亚单位结构形成的聚合物,主要是通过增加氯离子的透性来减少对神经元的激活作用。GABA(γ-氨基丁酸)是大脑的主要抑制性神经递质。其产生、转运、再吸收和新陈代谢都在神经系统中完成。GABA的转运主要与两个主要类型的受体结合完成:离子转运型GABAA受体(GABAAR)和代谢型受体(GABABR)。GABAARs属于配体门控离子通道。GABA通过与细胞内GABAA受体相互作用能抑制神经元对神经信号的接收。GABA与GABAA受体的结合导致构象变化,氯离子通道开放,使膜电导的增加,导致神经活动受到抑制。
以Anti-GABA(A) α1 Receptor (extracellular)为例,
Alomone公司提供的GABA(A) 受体相关
抗体产品在WB分析与
免疫组化分析中的应用:
Alomone公司提供的GABA(A) 受体相关抗体产品:
品名货号实验应用反应种属
Anti-GABA(A) α1 Receptor (extracellular)AGA-001IC, IH, LCI, WB, IFC*, IP*M, R, H*
Anti-GABA(A) α1 Receptor (extracellular)-ATTO-488AGA-001-AGIC, IH, LCI, FC*M, R, H*
Anti-GABA(A) α2 ReceptorAGA-002IH, WB, IC*, IFC*, IP*H, M, R
Anti-GABA(A) α3 Receptor (extracellular)AGA-003IC, IH, IP, LCI, WB, IFC*H, M, R
Anti-GABA(A) α4 Receptor (extracellular)AGA-008IC, IH, LCI, WB, IFC*, IP*H, M, R
Anti-GABA(A) α6 Receptor (extracellular)AGA-004IC, IH, LCI, WB, IFC*, IP*M, R, H*
Anti-GABA(A) β1 ReceptorAGA-010WB, IC*, IFC*, IH*, IP*H, M, R
Anti-GABA(A) ε Receptor (extracellular)AGA-015IC, LCI, WB, IFC*, IH*, IP*H, M, R
Anti-GABA(A) γ1 ReceptorAGA-016IH, WB, IC*, IFC*, IP*M, R, H*
Anti-GABA(A) γ2 Receptor (extracellular)AGA-005IC, IH, LCI, WB, IFC*, IP*H, M, R
Anti-GABA(A) δ Receptor (extracellular)AGA-014IH, WB, IC*, IFC*, IP*, LCI*M, R, H*
Anti-GABA(A) ρ1 Receptor (extracellular)AGA-006WB, IC*, IFC*, IH*, IP*, LCI*R, H*, M*
Anti-GABA(A) ρ2 Receptor (extracellular)AGA-007WB, IC*, IFC*, IH*, IP*, LCI*R, H*, M*
Anti-GABA(A) θ Receptor (extracellular)AGA-018IC, IH, LCI, WB, IFC*, IP*H, M, R
Anti-GABA(A) ρ3 Receptor (extracellular)AGA-020IC, LCI, WB, IFC*, IH*, IP*M, R, H*
Anti-Neurexin 1α (extracellular)ANR-031IC, LCI, WB, IFC*, IH*, IP*H, M, R |
Alomone公司提供的GABA(A) 受体Activators产品:品名货号来源靶位
γ-Aminobutyric acidG-110SyntheticGABA(A), GABA(B) receptors, GABA transporters
IvermectinI-110Syntheticα7 nAChR, P2X4, GABA(A)R |
Alomone公司提供的GABA(A) 受体Blockers产品:品名货号来源靶位
(+)-BicucullineB-135SyntheticGABA(A) receptors
α-BungarotoxinB-100Natural peptideα7, α1/β1/γ/δ nAChR, GABA(A) receptor subtypes
α-Bungarotoxin-ATTO-488B-100-AGModified natural proteinα7, α1/β1/γ/δ nAChR and GABA(A) receptor subtypes
α-Bungarotoxin-BiotinB-100-BModified natural proteinα7, α1/β1/γ/δ nAChR, GABA(A) receptor subtypes |
Alomone公司提供的5-HT3 受体抗体产品:
品名货号实验应用反应种属
Anti-5-Hydroxytryptamine Receptor 3AASR-031WBM, R
Anti-5-Hydroxytryptamine Receptor 3B (extracellular)ASR-032IH, WB, IC*, IFC*, IP*, LCI*M, R
Anti-5-Hydroxytryptamine Receptor 3B (extracellular)-ATTO-488ASR-032-AGFC, IC, IH, LCIM, R |
Alomone公司提供的AMPA 受体抗体产品:品名货号实验应用反应种属
Anti-AMPA Receptor 1 (GluA1) (extracellular)AGC-004IC, IH, LCI, WB, IFC*, IP*H, M, R
Anti-AMPA Receptor 1 (GluA1) (extracellular)-ATTO-594AGC-004-ARIC, LCI, FC*, IH*H, M, R
Anti-AMPA Receptor 1 (GluA1) (extracellular)AGP-009IC, LCI, WB, IFC*, IH*, IP*H, M, R
AMPA Receptor 1 Antibody and Membrane Lysate KitLK-103
Anti-AMPA Receptor 2 (GluA2) (extracellular)AGC-005IH, IP, WB, IC*, IFC*, LCI*M, R, H*
Anti-AMPA Receptor 2 (GluA2) (extracellular)-ATTO-488AGC-005-AGIH, FC*, IC*, LCI*M, R, H*
Anti-AMPA Receptor 3 (GluA3) (extracellular)AGC-010IH, IP, WB, IC*, IFC*, LCI*H, M, R
Anti-AMPA Receptor 4 (GluA4) (extracellular)AGC-019IH, WB, IC*, IFC*, IP*, LCI*H, M, R
AMPA Receptor Antibody Explorer KitAK-213
Anti-CaVγ2ACC-012IC, WB, IFC*, IH*, IP*H, M, R
Anti-CaVγ3ACC-113WB, IC*, IFC*, IH*, IP*H, M, R
Anti-CaVγ4ACC-114WB, IC*, IH*, IP*H, M, R |
Alomone公司提供的AMPA 受体Membrane Lysates产品:
品名货号
Overexpressed AMPA Receptor 1 Membrane LysateLX-103
AMPA Receptor 1 Antibody and Membrane Lysate KitLK-103 |
Alomone公司提供的AMPA 受体Blockers产品:品名货号来源靶位
CNQXC-140SyntheticAMPA/Kainate receptors
CNQX disodium saltC-141SyntheticAMPA/Kainate receptors
DNQXD-131SyntheticAMPA, Kainate receptors
DNQX disodium saltD-130SyntheticAMPA/Kainate receptors
Evans Blue tetrasodium saltE-110SyntheticAMPA, Kainate, P2X receptors
GYKI 52466 hydrochlorideG-125SyntheticAMPA/Kainate receptors
NBQXN-185SyntheticAMPA/Kainate receptors
NBQX disodium saltN-186SyntheticAMPA/Kainate receptors
Philanthotoxin-7,4P-120SyntheticAMPA receptors |
Alomone公司提供的AMPA 受体Auxiliary Subunits抗体产品:
品名货号实验应用反应种属
Anti-CaVγ2ACC-012IC, WB, IFC*, IH*, IP*H, M, R
Anti-CaVγ3ACC-113WB, IC*, IFC*, IH*, IP*H, M, R
Anti-CaVγ4ACC-114WB, IC*, IH*, IP*H, M, R |
Alomone公司提供的Delta受体抗体产品:品名货号实验应用反应种属
Anti-Glutamate Receptor δ1 (GluD1) (extracellular)AGC-038IC, IH, LCI, WB, IFC*, IP*H, M, R
Anti-Glutamate Receptor δ2 (GluD2) (extracellular)AGC-039IC, LCI, WB, IFC*, IH*, IP*H, M, R |
Alomone公司提供的红藻氨酸受体抗体产品:
品名货号实验应用反应种属
Anti-Kainate Receptor GluK1 (extracellular)AGC-008IC, LCI, WB, IFC*, IH*, IP*R, H*, M*
Anti-Kainate Receptor GluK2AGC-009IC, WB, IFC*, IH*, IP*H, M, R
Anti-Kainate Receptor GluK4 (extracellular)AGC-041IH, WB, FC*, IC*, IP*, LCI*H, M, R |
Alomone公司提供的红藻氨酸受体Blockers产品:
品名货号来源靶位
CNQXC-140SyntheticAMPA/Kainate receptors
CNQX disodium saltC-141SyntheticAMPA/Kainate receptors
DNQXD-131SyntheticAMPA, Kainate receptors
DNQX disodium saltD-130SyntheticAMPA/Kainate receptors
Evans Blue tetrasodium saltE-110SyntheticAMPA, Kainate, P2X receptors
GYKI 52466 hydrochlorideG-125SyntheticAMPA/Kainate receptors
NBQXN-185SyntheticAMPA/Kainate receptors
NBQX disodium saltN-186SyntheticAMPA/Kainate receptors |
Alomone公司提供的NMDA受体抗体产品:
品名货号实验应用反应种属
Anti-NMDA Receptor 1 (GluN1) (extracellular)AGC-001IC, IH, LCI, WB, IFC*, IP*H, M, R
Anti-NMDA Receptor 2A (GluN2A) (extracellular)AGC-002IC, IH, IP, LCI, WB, IFC*H, M, R
Anti-NMDA Receptor 2B (GluN2B) (extracellular)AGC-003IC, IH, IP, LCI, WB, IFC*H, M, R
Anti-NMDA Receptor 2B (GluN2B) (extracellular)-ATTO-594AGC-003-ARIH, FC*, IC*, LCI*H, M, R
Anti-NMDA Receptor 2C (GluN2C) (extracellular)AGC-018IH, WB, IC*, IFC*, IP*, LCI*M, R, H*
Anti-NMDA Receptor 2D (GluN2D) (extracellular)AGC-020IH, WB, IC*, IFC*, IP*, LCI*M, R, H*
Anti-NMDA Receptor 3A (GluN3A) (extracellular)AGC-030WB, IC*, IFC*, IH*, IP*, LCI*M, R, H*
Anti-NMDA Receptor 3B (GluN3B) (extracellular)AGC-031IH, WB, IC*, IFC*, IP*, LCI*M, R, H*
Anti-Shank1APZ-011WB, IC*, IH*, IP*M, R, H*
NMDA Receptor Antibody Explorer KitAK-214 |
Alomone公司提供的NMDA受体Activators产品:
品名货号来源靶位
NMDAN-170SyntheticNMDA receptors |
Alomone公司提供的NMDA受体Blockers产品:
品名货号来源靶位
Loperamide hydrochlorideL-100SyntheticL-type, T-type Ca2+, HCN channels, NMDA, μ-opioid receptors
Orphenadrine citrate saltO-100SyntheticMuscarinic, H1 histamine, NMDA receptors, NaV Na+ channels
Orphenadrine hydrochlorideO-101Synthetic.Muscarinic, H1 histamine, NMDA receptors, NaV Na+ channels |
Alomone公司提供的甘氨酸受体抗体产品:
品名货号实验应用反应种属
Anti-Glycine Receptor α1AGR-001IH, WB, IC*, IFC*, IP*M, R, H*
Anti-Glycine Receptor α3AGR-003WBR
Anti-Glycine Receptor α4 (extracellular)AGR-015IC, LCI, WB, IFC*, IH*, IP*H, M, R
Anti-Glycine Receptor β AGR-014WB, IC*, IFC*, IH*, IP*H, M, R |
品名货号来源靶位
IvermectinI-110Syntheticα7 nAChR, P2X4, GABA(A)R |
Alomone公司提供的烟酰胺乙酰胆碱受体抗体产品:
品名货号实验应用反应种属
Anti-Nicotinic Acetylcholine Receptor α1 (extracellular)ANC-001WB, IC*, IFC*, IH*, IP*, LCI*H, M, R
Anti-Nicotinic Acetylcholine Receptor α2 (extracellular)ANC-002IC, IH, LCI, WB, IFC*, IP*H, M, R
Anti-Nicotinic Acetylcholine Receptor α3 (extracellular)ANC-003IH, WB, IC*, IFC*, IP*, LCI*M, R, H*
Anti-Nicotinic Acetylcholine Receptor α4 (extracellular)ANC-004IFC, IH, WB, IC*, IP*, LCI*H, M, R
Anti-Nicotinic Acetylcholine Receptor α6 (extracellular)ANC-006IC, IH, LCI, WB, IFC*, IP*M, R
Anti-Nicotinic Acetylcholine Receptor α7 (extracellular)ANC-007IC, IFC, IH, WB, IP*, LCI*H, M, R
Anti-Nicotinic Acetylcholine Receptor β1 (extracellular)ANC-011WB, IC*, IFC*, IH*, IP*, LCI*H, M, R
Anti-Nicotinic Acetylcholine Receptor β2 (extracellular)ANC-012IC, LCI, WB, IFC*, IH*, IP*H, M, R
Anti-Nicotinic Acetylcholine Receptor β2 (extracellular)-ATTO-594ANC-012-ARIC, IH, LCI, FC*H, M, R
Anti-Nicotinic Acetylcholine Receptor β3 (extracellular)ANC-013IC, LCI, WB, IFC*, IH*, IP*M, R, H*
Anti-Nicotinic Acetylcholine Receptor β4 (extracellular)ANC-014IC, IH, LCI, WB, IFC*, IP*H, M, R
Anti-Nicotinic Acetylcholine Receptor β4 (extracellular)-ATTO-594ANC-014-ARIC, IH, LCI, FC*H, M, R
nAChR Antibody Explorer KitAK-203 |
Alomone公司提供的烟酰胺乙酰胆碱受体Activators产品:
品名货号来源靶位
1,1-Dimethyl-4-phenylpiperazinium iodideD-125SyntheticnAChR
(-)-CytisineC-130SyntheticnAChR
DMAB-anabaseine dihydrochlorideD-110SyntheticnAChR
IvermectinI-110Syntheticα7 nAChR, P2X4, GABA(A)R
(-)-Nicotine ditartrateN-175SyntheticnAChR
PNU 282987P-110Syntheticα7 nAChR
RJR 2403 oxalateR-115Syntheticα4/β2 nAChRs
Varenicline tartrateV-105Syntheticα4/β2, α7 nAChR |
Alomone公司提供的烟酰胺乙酰胆碱受体Blockers产品:
品名货号来源靶位
αA-Conotoxin OIVASTC-520Synthetic peptideα1/β1/γ/δ nAChR
αA-Conotoxin PIVASTC-600Synthetic peptideα1/β1/γ/δ nAChR
AzemiopsinSTA-100Synthetic peptideα1/β1/γ/δ nAChR
α-BungarotoxinB-100Natural peptideα7, α1/β1/γ/δ nAChR, GABA(A) receptor subtypes
α-Bungarotoxin-ATTO-488B-100-AGModified natural proteinα7, α1/β1/γ/δ nAChR and GABA(A) receptor subtypes
α-Bungarotoxin-BiotinB-100-BModified natural proteinα7, α1/β1/γ/δ nAChR, GABA(A) receptor subtypes
ChlorpromazineC-165SyntheticnAChR, Dopamine receptors
αC-Conotoxin PrXASTC-620Synthetic peptideα1/β1/γ/δ nAChR
α-Conotoxin AuIASTC-960Synthetic peptideα3/β4 nAChR
α-Conotoxin AuIBSTC-300Synthetic peptideα3/β4 nAChR
α-Conotoxin EISTC-900Synthetic peptideα1/β1/γ/δ nAChR
α-Conotoxin GISTC-500Synthetic peptideα1/β1/δ/γ nAChR
α-Conotoxin ImIC-290Synthetic peptideα3/β2 nAChR
α-Conotoxin LtIASTC-550Synthetic peptideα3/β2 nAChR
α-Conotoxin MISTC-370Synthetic peptideα1/β1/γ/δ nAChR
α-Conotoxin PeIASTC-970Synthetic peptidenAChR, CaV2.2 Ca2+ channels
µ-Conotoxin CnIIICSTC-640Synthetic peptideNaV Na+ channels, α3/β2 nAChR
Hexamethonium bromideH-100SyntheticnAChR
(-)-Lobeline hydrochlorideL-120SyntheticnAChR
Mecamylamine hydrochlorideM-105SyntheticnAChR
Pancuronium bromideP-130SyntheticnAChRs
nAChR Modulator Explorer KitEK-202
Muscle Specific nAChR blocker Explorer KitEK-207 |
品名货号
nAChR Modulator Explorer KitEK-202
Muscle Specific nAChR blocker Explorer KitEK-207
nAChR Activator Explorer KitEK-204
nAChR Antibody Explorer KitAK-203 |
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