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蚂蚁淘在线 / 品牌中心 / Absolute Antibody / absoluteantibody/Ab00157-1.1 Anti-desmoglein-3 [PVA218]/Ab00157-1.1/ 100 µg
商品描述
Description:Recombinantmonoclonalantibodytodesmoglein-3.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromtheEBVtransformedhumanBcellclonePVA218.MadewithAntibodySequenceslicensedfromHumabsBiomedSA.MadewithAntibodySequenceslicensedfromHumabsBiomedSA.
SpeciesandIsotype:MouseIgG1,kappa
CloneNumber:PVA218
UniProtAccessionNumberofTargetProtein:P32926
AlternativeName(s)ofTarget:130kDapemphigusvulgarisantigen;PVA;Cadherinfamilymember6;DSG3;CDHF6
PublishedApplication(s):ELISA;IF
PublishedSpeciesReactivity:Human
Immunogen:MadebyimmortalizingIgG-expressingBcellsfromPemphigusvulgaris(PV)patients.
Specificity:ThisantibodyspecificallyrecognizesaconformationalepitopeintheEC3domainofhumandesmoglein-3(DSGThisantibodywasisolatedasahumanIgG4fromapatientwithmucocutaneouspemphigusvulgarisandusestheVH5a*03,D6-6*01,JH3*01,VL1-33*01andJL2*01.Thisantibodydoesnothaveinvitroandinvivopathogenicactivity,asassessedinakeratinocytedissociationassayandbytheformationofmicroscopicblistersinnewbornmice.
AntibodyFirstPublishedin:
DiZenzo,G.etal.Pemphigusautoantibodiesgeneratedthroughsomaticmutationstargetthedesmoglein-3cis-interface.JClinInvest122,3781–3790(2012).PMID:22996451Noteonpublication:Describestheisolationandanalysisofapanelofhumanantibodiesfrompatients-incdataonELISA,IFandinvitroandinvivopathogenicactivityassays.
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals. Absolute Antibody我们现在与Digital Proteomics合作提供多克隆永生化服务。这意味着您可以生产可复制且不受限制的多克隆试剂，或者利用天然免疫系统来识别新的抗体候选物。对于这项服务，您可以提供免疫宿主生物的血清和B细胞，纯化的抗原用于免疫，或者只是告诉我们您的靶标，我们将做剩下的事情。鉴于其中之一，我们可以提供多达10条由发现引擎选择的重链序列和10条轻链序列，在交互式报告中提供具有蛋白质组学证据的扩展库，根据要求将抗体工程化为任何种类和同种型，以及我们提供的抗体表征数据获得。此服务是100％免版税的。 SpeciesandIsotype:MouseIgG1,kappa
CloneNumber:PVA218
UniProtAccessionNumberofTargetProtein:P32926
AlternativeName(s)ofTarget:130kDapemphigusvulgarisantigen;PVA;Cadherinfamilymember6;DSG3;CDHF6
PublishedApplication(s):ELISA;IF
PublishedSpeciesReactivity:Human
Immunogen:MadebyimmortalizingIgG-expressingBcellsfromPemphigusvulgaris(PV)patients.
Specificity:ThisantibodyspecificallyrecognizesaconformationalepitopeintheEC3domainofhumandesmoglein-3(DSGThisantibodywasisolatedasahumanIgG4fromapatientwithmucocutaneouspemphigusvulgarisandusestheVH5a*03,D6-6*01,JH3*01,VL1-33*01andJL2*01.Thisantibodydoesnothaveinvitroandinvivopathogenicactivity,asassessedinakeratinocytedissociationassayandbytheformationofmicroscopicblistersinnewbornmice.
AntibodyFirstPublishedin:
DiZenzo,G.etal.Pemphigusautoantibodiesgeneratedthroughsomaticmutationstargetthedesmoglein-3cis-interface.JClinInvest122,3781–3790(2012).PMID:22996451Noteonpublication:Describestheisolationandanalysisofapanelofhumanantibodiesfrompatients-incdataonELISA,IFandinvitroandinvivopathogenicactivityassays.
ProductForm
Purification:ProteinAaffinitypurifiedSuppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
