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蚂蚁淘在线 / 品牌中心 / Absolute Antibody / absoluteantibody/Ab00497-10.6 Anti-IgE [TES-C21]/Ab00497-10.6/ 200 µg
商品描述
Description:RecombinantmonoclonalantibodytoIgE.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridomaTES-C21.ThisisaFabfragmentwithahis-tag.
CloneNumber:TES-C21
UniProtAccessionNumberofTargetProtein:
AlternativeName(s)ofTarget:ImmunoglobulinE
PublishedApplication(s):block;ELISA
PublishedSpeciesReactivity:Human
Immunogen:PolyclonalhumanIgE.
Specificity:
ApplicationNotes:TheantibodybindsspecificallytoIgE,animmunoglobulinisotypesecretedbyuponstimulationofBcellsbyinterleukinsIl-4andIL-13.IgEprovidesimmunitytoparasitessuchashelminthsandPlasmodiumfalciparum.TheimmunoglobulinalsoplaysacentralroleinthedevelopmentofTypeIhypersensitivityreactionsandallergicdiseasessuchasasthma,sinusitisandfoodallergies.TheseallergicresponsesaretriggeredbythebindingofIgEtothehighaffinityreceptorFcεRI,expressedonthesurfaceofbasophilsandmastcells.BindingofIgEcausescross-linkingofthereceptor,inducingdegranulationandreleaseofinflammatorymediators,particularlyofhistamine.ThemonoclonalantibodyTES-C21bindstosecretedIgEandtoIgEexpressedonthesurfaceofIgE-producingBcells,therebyinhibitingIgEbindingtoFcεRIandthereleaseofhistaminefrommastcells.Themonoclonalantibodycanhavediagnosticapplications,suchasforidentifyingandquantifyingIgE-expressingBcellsandIgElevelsinserumsamples,andtherapeuticapplicationsinthetreatmentofallergies.FurThermore,theantibodycanconjugatedtocytotoxicdrugsanddeliverthemspecificallytoIgE-producingBcells.
AntibodyFirstPublishedin:
KolbingerF,SaldanhaJ,HardmanN,BendigMM.Humanizationofamouseanti-humanIgEantibody:apotentialtherapeuticforIgE-mediatedallergies.ProteinEng.1993Nov;6(8):971-80.PMID:8309946Noteonpublication:DescribesthetherapeuticpotentialofthemurinemonoclonalantibodyTES-C21inthetreatmentofIgE-mediatedallergies,andtheproductionofahumanizedversionoftheantibodytoreducetheimmunogenicityinhumans.
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals. Absolute Antibody我们现在与Digital Proteomics合作提供多克隆永生化服务。这意味着您可以生产可复制且不受限制的多克隆试剂，或者利用天然免疫系统来识别新的抗体候选物。对于这项服务，您可以提供免疫宿主生物的血清和B细胞，纯化的抗原用于免疫，或者只是告诉我们您的靶标，我们将做剩下的事情。鉴于其中之一，我们可以提供多达10条由发现引擎选择的重链序列和10条轻链序列，在交互式报告中提供具有蛋白质组学证据的扩展库，根据要求将抗体工程化为任何种类和同种型，以及我们提供的抗体表征数据获得。此服务是100％免版税的。 ThischimerichumanantibodywasmadeusingthevariabledomainsequencesoftheoriginalMouseIgGformat,forimprovedcompatibilitywithexistingreagents,assaysandtechniques.
SpeciesandIsotype:HumanFabfragment,His-Tagged,kappaCloneNumber:TES-C21
UniProtAccessionNumberofTargetProtein:
AlternativeName(s)ofTarget:ImmunoglobulinE
PublishedApplication(s):block;ELISA
PublishedSpeciesReactivity:Human
Immunogen:PolyclonalhumanIgE.
Specificity:
ApplicationNotes:TheantibodybindsspecificallytoIgE,animmunoglobulinisotypesecretedbyuponstimulationofBcellsbyinterleukinsIl-4andIL-13.IgEprovidesimmunitytoparasitessuchashelminthsandPlasmodiumfalciparum.TheimmunoglobulinalsoplaysacentralroleinthedevelopmentofTypeIhypersensitivityreactionsandallergicdiseasessuchasasthma,sinusitisandfoodallergies.TheseallergicresponsesaretriggeredbythebindingofIgEtothehighaffinityreceptorFcεRI,expressedonthesurfaceofbasophilsandmastcells.BindingofIgEcausescross-linkingofthereceptor,inducingdegranulationandreleaseofinflammatorymediators,particularlyofhistamine.ThemonoclonalantibodyTES-C21bindstosecretedIgEandtoIgEexpressedonthesurfaceofIgE-producingBcells,therebyinhibitingIgEbindingtoFcεRIandthereleaseofhistaminefrommastcells.Themonoclonalantibodycanhavediagnosticapplications,suchasforidentifyingandquantifyingIgE-expressingBcellsandIgElevelsinserumsamples,andtherapeuticapplicationsinthetreatmentofallergies.FurThermore,theantibodycanconjugatedtocytotoxicdrugsanddeliverthemspecificallytoIgE-producingBcells.
AntibodyFirstPublishedin:
KolbingerF,SaldanhaJ,HardmanN,BendigMM.Humanizationofamouseanti-humanIgEantibody:apotentialtherapeuticforIgE-mediatedallergies.ProteinEng.1993Nov;6(8):971-80.PMID:8309946Noteonpublication:DescribesthetherapeuticpotentialofthemurinemonoclonalantibodyTES-C21inthetreatmentofIgE-mediatedallergies,andtheproductionofahumanizedversionoftheantibodytoreducetheimmunogenicityinhumans.
ProductForm
Purification:PurifiedbyImmobilizedMetalAffinityChromatographySuppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
