- 关注表位标记
- Primary Antibodies
- Recombinant Antibodies from Human Patients
- Anti-Allergen Antibodies
- 多标签控制蛋白
- Recombinant Isotype Controls
- 抗过敏原抗体
- 重组F4/80克隆CI:A3-1
- 体内研究用重组抗体
- Recombinant F4/80 Clone CI:A3-1
- Research-Grade Biosimilars
- 关注来自人类患者的重组抗体
- 同型对照
- 重组免疫球蛋白Fc结构域（Ig-Fc结构域）
- 人源性重组抗体
- 研究级生物仿制药
- 其他产品
- 抗病毒抗体
- 重组自由轻链
- Antibodies to Epitope Tags
- Anti-Virus Antibodies
UniProtAccessionNumberofTargetProtein:Q6PSU2;O82580
AlternativeName(s)ofTarget:Arah2;Arachishypogaea;peanut;Arah3;Conglutin;2Salbumin;Conglutin-7;2Sprotein1;SeedstorageproteinSSP1;SeedstorageproteinSSP2;Glycinin;Arah3Immunogen:ThisantibodywasacquiredbyisolatingIgEBcellsfromperipheralbloodofhumanindividualsallergictopeanutsandsubsequentcloningandexpressingtheantibody(crooteetal.,2018).
Specificity:ThisantibodyrecognisespredominantlyArah2,butitalsocross-reactswithArah3andweaklywithArah1.Arah2isoneofthemajorpeanutallergens.
ApplicationNotes:ELISAtestsconfirmedthatthisantibodystronglybindsArah2andtoalesserdegreeArah3(Crooteetal.,2018).BiolayerinterferometryexperimentsrevealedthatPA12P3F10antibodyexhibitsveryhighaffinitytoArah2andArah3peanutallergens(Crooteetal.,2018).Consequently,thisantibodyanditsengineeredversions(suchasanIgGversionwiththesamevariabledomainsastheoriginalIgE)mightbeusedinthedevelopmentofthetherapeuticagentsforallergies,assuchIgGscouldcompetewithallergenicIgEsfortheallergen(Crooteetal.,2018).
Antibodyfirstpublishedin:Crooteetal.High-affinityallergen-specifichumanantibodiesclonedfromsingleIgEBcelltranscriptomes.Science.2018Dec14;362(6420):1306-1309.doi:10.1126/science.aau2599.PMID:30545888Noteonpublication:ThisarticledescribesthegenerationandcharacterisationofthePA12P3F10antibody.
