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商品描述
Species:Human
HostSpecies:Sf9insectcells
MW:208kDa(complex)
Genbank#:NM_006219(p110β),NM_181523(p85α)
Tag(s):N-terminalFLAG-tag(p110β),notagonp85α
a.a:fulllength
Description:
ComplexofN-terminalFLAG-taggedrecombinantfull-lengthhumanp110β(GenBankAccessionNo.NM_006219),anduntagged,recombinantfulllength,humanp85α.(GenBankAccessionNo.NM_181523).CoexpressedinaBaculovirusinfectedSf9cellexpressionsystem.p110βMW=124kDa,p85αMW=84kDa.
Synonym(s):
PIK3CB,p110beta,Phosphoinositide-3-Kinase,Catalytic,Beta,PIK3R1,Phosphoinositide-3-Kinase,RegulatorySubunit1(Alpha),GRB1,p85alpha
SpecificActivity:
1023pmol/min/μg
UnitDefinition:
Aunitofp110β/p85αkinaseactivityisdefinedastheamountofenzymerequiredtoproduce1pmolofPhosphoinositol-3,4,5-Trisphosphate/minat30°C.
Formulation:
25mMTris,pH8.0,69mMNaCl,1.35mMKCl,0.025%Tween-20,3mMDTT,50%glycerol,and0.05mg/mlFLAGpeptide.
Format:
Aqueousbuffersolution
Storage/StABIlity:
>6monthsat–80°C.
Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.MarquesM.etal.,(2008).Mol.Cell.Biol.28(8),2803-2814.
2.StraubA.etal.,(2008).Thromb.Haemost.99(3),609-615.
2.StraubA.etal.,(2008).Thromb.Haemost.99(3),609-615.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/Lipids
ProductType:
RecombinantProtein
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