Description:

Bace1 (β-secretase 1) is an aspartic protease that is involved in the processing of the Amyloid precursor protein (APP). Cleavage of APP by BACE1 followed by γ-secretase results in β-amyloid peptide production, which ultimately leads toxic Aβ accumulation. In Alzheimer’s disease (AD), it has been widely accepted that Aβ aggregation plays a critical role in AD pathogenesis, suggesting that BACE1 could be a potential target to treat AD. The BACE1 FRET Assay Kit is designed to measure BACE1 activity for screening and profiling applications based on fluorescence resonance energy transfer (FRET) using a labeled peptide substrate (below).

Synonym(s): beta-site amyloid precursor protein cleaving enzyme 1, ASP2 Supplied As: The BACE1 FRET Assay Kit comes in a convenient 96-well format, with enough purified recombinant human BACE1 enzyme, BACE1 FRET peptide substrate, and assay buffer for 100 enzyme reactions. Format:

COMPONENTS:

Instructions for use: See assay kit data sheet for detailed protocol. Storage / Stability: At least 12 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival. Reference(s): Ghosh, A.K., et al. J. Neurochemistry 120(suppl. 1):71-83 (2012) Notes:

MATERIALS OR INSTRUMENTS REQUIRED BUT NOT SUPPLIED:Microplate reader capable of reading fluorescenceAdjustable micropipettor and sterile tips

Warning(s): Avoid freeze/thaw cycles. Scientific Category: Neuroscience Product Type: Assay Kit Data shown is lot-specific. Contact us for specific information on other lots.

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