MW: 600 Da CAS Registry #: 935693-62-2 Formula: C₂₈H₃₈N₆O₂ • 3HCl [XH₂O] Description:BIX01294 (hydrochloride hydrate) is a selective inhibitor of G9a, a histone methyltransferase (HMT). It can also inhibit G9a-like protein (GLP), but is less effective. There are no known inhibitory effects on other HMTs. Also, BIX01294 has been used in combination with Bay-K8644 to facilitate generation of induced pluripotent stem cells from somatic cells in vitro. Purity:

≥98% by HPLC

Biological Activity: BIX01294 inhibits G9a with an IC50 = 1.7 µM, and GLP with an IC50 = 38 µM. Solubility: Dissolve in water or other aqueous buffers. Solubility in water is ~20 mg/ml. Format: A crystalline solid. Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Reference(s): 1. Tachibana, M., et al., Genes Dev. 2002; 16:1779-1791.2. Wagschal, A., et al., Mol. Cell. Biol. 2008; 28(3):1104-1113.3. Thomas, L.R., et al., J. Immunol. 2008; 181:485-493. Scientific Category: Methyltransferase Product Type: Inhibitor Data shown is lot-specific. Contact us for specific information on other lots.

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