MW: 404.4 Da Formula: C₁₇H₂₀N₆O₄S Background:Bromodomains have an important role in the targeting of chromatin-modifying enzymes to specific sites, including methyltransferases, HATs and transcription factors and regulate diverse biological processes from cell proliferation and differentiation to energy homeostasis and neurological processes. Description:Bromosporine is a broad spectrum inhibitor for bromodomains. Synonym(s): ethyl (3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate Biological Activity: Bromosporine exhibits IC50 values of 0.41 µM, 0.29 µM, 0.122 µM and 0.017 µM for BRD2, BRD4, BRD9 and CECR2, respectively. Solubility: Soluble in DMSO (100 mM) and ethanol (25 mM) Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Reference(s): Gallenkamp et al. (2014). Chem Med Chem 9:438. Scientific Category: Bromodomain Inhibitor Product Type: Inhibitor Data shown is lot-specific. Contact us for specific information on other lots.

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