MW: 423.9 Da CAS Registry #: 1260907-17-2 Formula: C₂₂H₂₂ClN₅O₂ Target: BET Background:Bromodomains have an important role in the targeting of chromatin-modifying enzymes to specific sites, including methyltransferases, HATs and transcription factors and regulate diverse biological processes from cell proliferation and differentiation to energy homeostasis and neurological processes. Description:I-BET-762 is a small molecule inhibitor of the BET family of bromodomaincontainingproteins. It has been shown to bind to the acetylated lysine recognition motifs on thebromodomain of BET proteins. This binding prevents the interaction of between BET proteinsand acetylated histone peptides. Synonym(s): 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide Solubility: Soluble in Water Storage / Stability: Powder is stable at -20°C for up to 3 years. Re-suspended powder is stableat -80°C for up to 6 months. Reference(s): Nicodeme E, et al. Nature. 2010 Dec 23;468 (7327):1119-23. Scientific Category: Bromodomain Inhibitor Product Type: Inhibitor Data shown is lot-specific. Contact us for specific information on other lots.

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