MW: 316.4 Da CAS Registry #: 135637-46-6 Formula: C₁₈H₂₄N₂O₃ Description:CP 80633 is a selective inhibitor of PDE4, which does not display significant isozyme selectivity. It also inhibits hydrolysis of cAMP in isolated monocytes, eosinophils, human peripheral blood and T-cells. It has been shown to exhibit anti-inflammatory and bronchodilatory activity in vivo. Purity:

≥95% by HPLC

Biological Activity: CP-80633 inhibits PDE4 isozymes (human lung IC50 = 1.27 µM) in the absence of effects on PDE1, PDE2, PDE3 and PDE5 isozymes (IC50 > 100 µM). Solubility: Soluble in 100 mM DMSO or 100 mM Ethanol. Format: A crystalline solid. Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Reference(s): 1. Turner, CR., et al., J. Pharmacol. Exp. Ther. 1996 Sept;278(3):1349-55.2. Cohan, VL., et al., J. Pharmacol. Exp. Ther. 1996 Sept;278(3):1356-61.3. Cheng, JB., et al., J. Pharmacol. Exp. Ther. 1997 Feb;280(2):621-6. Scientific Category: PDE Product Type: Inhibitor Data shown is lot-specific. Contact us for specific information on other lots.

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