Species: Human Host Species: Sf9 insect cells MW: 105 kDa Genbank #: NM_001040261 Tag(s): N-terminal GST-tag a.a: 1–690 Background:DCAMKL2 (also known as doublecortin-like kinase 2 or DCLK2) is a close homologue of doublecortin or DCX which is associated with intractable epilepsy in humans, due to a severe disorganization of the neocortex and hippocampus known as classical lissencephaly. DCX; DCLK2-null mice display frequent spontaneous seizures that originate in the hippocampus, with most animals dying in the first few months of life. DCX and DCLK2 are co-expressed in developing hippocampus, and, in their absence, there is dosage-dependent disrupted hippocampal lamination associated with a cell-autonomous simplification of pyramidal dendritic arborizations leading to reduced inhibitory synaptic tone (1). Description:Recombinant human DCAMKL2 (a.a. 1-690), with N-terminal GST-tag, expressed by baculovirus in Sf9 cells Synonym(s): DCLK2; DCK2; DCDC3; DCDC3B; DKFZp761I032; MGC45428 Purity: ≥75% Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol. Format: Aqueous buffer solution Storage / Stability:

>6 months at -80°C.

Application(s): Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Reference(s): Kerjan G. Et al: Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6766-71. Warning(s): Avoid freeze/thaw cycles Scientific Category: Kinase/Serine-Threonine Product Type: Recombinant Protein Data shown is lot-specific. Contact us for specific information on other lots.

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