MW: 224.2 Da CAS Registry #: 67200-34-4 Formula: C11H4N4O2S Description:Small Molecule Enhancer of Rapamycin 3 (SMER3) is a specific inhibitor of the ubiquitin E3 ligase SCFMET30. SMER3 binds directly to the F-box subunit Met30 and blocks binding to the SCF core complex. Cell permeable. Significant inhibition is typically seen at 30-100 μM. Synonym(s): 9H–Indeno[1,2–e][1,2,5]oxadiazolo[3,4–b]pyrazin–9–one Purity: >98% by TLC. Solubility: Soluble in DMSO (up to 20 mg/ml, with heating) Format: Yellow powder Storage / Stability:

Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 2 months.

Application(s): Useful for the inhibition of SCFMET30 in cell-based or in vitro assays. Reference(s): Aghajanyy, M. et al. Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor. Nat. Biotech. 2010, 28(7):738. Warning(s): Protect from moisture. Scientific Category: Ubiquitin Enzymes Product Type: Inhibitors/Activators Data shown is lot-specific. Contact us for specific information on other lots.

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