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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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商品描述
Background:
Tryptophan5-hydroxylase1and2(TPH1andTPH2)areenzymesthatcatalyzethemonooxygenationoftryptophanto5-hydroxytryptophan(5-HTP)whichissubsequentlyconvertedtoSEROtonin.Bycatalyzingtherate-limitingstepinthebiosynthesisofserotonin,theseenzymesalsoplaykeyrolesinthesignalingofotherneurotransmittersdownstreamofserotoninsynthesis,likemelatonin.Additionally,TPHenzymesmayplayaroleinimmuneregulationthroughtryptophandepletion.
Description:
TheTPH1AssayKitisdesignedtomeasureTPH1enzymeinhibitionina96reactionformat.Thisfluorescence-basedassaykitisespeciallysuitableforhighthroughputscreeningapplications.Theprocedureisquick,straightforward,andsimple-justmixtwosolutions,incubate,addquenchingsolution,andmeasurethefluorescence.
Synonym(s):
tryptophan5-hyrdoxylase,TRPH
Format:
COMPONENTS:
Instructionsforuse:
Seeproductdatasheetfordetailedprotocol.
Storage/StABIlity:
Atleast6monthsfromdateofreceiptwhenstoredasdirected.
Application(s):
GreatforscreeningsmallmolecularinhibitorsfordrugdiscoveryandHTSapplications.
Reference(s):
1.MoranG.R.,etal.J.Biol.Chem.1998;273:12259-12266.
2.NowakE.C.,etal.,J.Exp.Med.2012;209:2127-2135.
Notes:
MATERIALSREQUIREDBUTNOTSUPPLIED:
MicroplatereadercapableofmeasuringFluorescence
MicroplatereadercapableofmeasuringFluorescence
Warning(s):
Avoidfreeze/thawcycles.
ScientificCategory:
MetabolicEnzyme,Immunotherapy
ProductType:
AssayKit
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