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Info

DSPE-PEG(2000) Azide

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-2000] (ammonium salt)

Cu-free click chemistry with readily synthesized biarylazacyclooctynones. The reaction of azides with strained alkynes, such as cyclooctynes, readily forms a triazole product without the need for a toxic catalyst.

Also, refer to DSPE-PEG DBCO Avanti Number 880229

Representative Structure

The molecular weight and exact mass are averages based on the polydispersity of PEG.

Data

Hygroscopic

Yes

Light Sensitive

No

Molecular Formula

C₁₃₂H₂₆₄N₅O₅₄P (average MW due to polydispersity of PEG)

Percent Composition

C 56.29%, H 9.45%, N 2.49%, O 30.67%, P 1.10%

Purity

>99%

Stability

1 Year

Storage Temperature

-20°C

CAS Number

1938081-40-3 CAS Registry Number is a Registered Trademark of the American Chemical Society

FormulaWeight

2816.519

Exact Mass

2814.78

Synonyms

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carbonyl-azido(polyethylene glycol)-2000] (ammonium salt)

Downloads

ChemDraw File
3D Structure
Structure
Safety Data Sheet
Safety Data Sheet

References

Xiao Y, Liu Q, Clulow AJ, Li T, Manohar M, Gilbert EP, de Campo L, Hawley A, Boyd BJ. PEGylation and surface functionalization of liposomes containing drug nanocrystals for cell-targeted delivery. Colloids Surf B Biointerfaces. 2019 Jul 15;182:110362. doi: 10.1016/j.colsurfb.2019.110362. [Epub ahead of print]

PubMed ID: 31351271

Girish A, Hickman DA, Banerjee A, Luc N, Ma Y, Miyazawa K, Sekhon UDS, Sun M, Huang S, Sen Gupta A. Trauma-targeted delivery of tranexamic acid improves hemostasis and survival in rat liver hemorrhage model. J Thromb Haemost. 2019 Jun 20. doi: 10.1111/jth.14552. [Epub ahead of print]

PubMed ID: 31220416

Paek J, Park SE, Lu Q, Park KT, Cho M, Oh JM, Kwon KW, Yi YS, Song JW, Edelstein HI, Ishibashi J, Yang W, Myerson JW, Kiseleva RY, Aprelev P, Hood ED, Stambolian D, Seale P, Muzykantov VR, Huh D. Microphysiological Engineering of Self-Assembled and Perfusable Microvascular Beds for the Production of Vascularized Three-Dimensional Human Microtissues. ACS Nano. 2019 Jun 18. doi: 10.1021/acsnano.9b00686. [Epub ahead of print]

PubMed ID: 31194909

Hood ED, Greineder CF, Shuvaeva T, Walsh L, Villa CH, Muzykantov VR. Vascular targeting of radiolabeled liposomes with bio-orthogonally conjugated ligands: single chain fragments provide higher specificity than antibodies. Bioconjug Chem. 2018 Sep 21. doi: 10.1021/acs.bioconjchem.8b00564. [Epub ahead of print]

PubMed ID: 30240185

Jewett, J.C., E.M. Sletten, and C.R. Bertozzi. (2010). Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones. J Am Chem Soc 132:3688-90.

PubMed ID: 20187640

avanti polar lipids/DSPE-PEG(2000) Azide/10mg/880228C-10mg

880228 | DSPE-PEG(2000) Azide

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-2000] (ammonium salt)

DSPE-PEG(2000) Azide

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-2000] (ammonium salt)

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