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Effective March 1, 2018, Merck KGaA, Darmstadt, Germany* is the exclusive Distributor of Avanti Polar Lipids, Inc. Research Products for all countries except the United States. For product pricing and order placement, please click on the appropriate Location Box below.

For customers located outside the United States, you will be redirected to www.sigmaaldrich.com/avanti prior to completing your purchase. Thank you for your continued business and support of Avanti Polar Lipids, Inc!

*The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the U.S. and Canada

Custom Packaging (${custompackaging} @ $4 per aliquot): ${custompackagingperunit|money} Custom packaging is calculated at $4.00 per aliquot + $100.00 surcharge.For all other custom packaging options not listed above, please contact us for a quote 5-PAHSA 5-(palmitoyloxy)octadecanoic acid

PAHSA levels correlate highly with insulin sensitivity and are reduced in adipose tissue and serum of insulin-resistant humans. In adipocytes, PAHSAs signal through GPR120 to enhance insulin-stimulated glucose uptake. Thus, FAHFAs are endogenous lipids with the potential to treat type 2 diabetes.

Avanti has obtained a license from the patent holder to manufacture these products for research use. CAS Number 1481636-41-2 CAS Registry Number is a Registered Trademark of the American Chemical Society

Pham TH, Vidal NP, Manful CF, Fillier TA, Pumphrey RP, Doody KM, Thomas RH. Moose and Caribou as Novel Sources of Functional Lipids: Fatty Acid Esters of Hydroxy Fatty Acids, Diglycerides and Monoacetyldiglycerides. Molecules. 2019 Jan 10;24(2). pii: E232. doi: 10.3390/molecules24020232.

PubMed ID: 30634564

Kolar, M.J., S.S. Kamat, W.H. Parsons, E.A. Homan, T. Maher, O.D. Peroni, I. Syed, K. Fjeld, A. Molven, B.B. Kahn, B.F. Cravatt, and A. Saghatelian. (2016). Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry 55:4636-41.

PubMed ID: 27509211

Yore, M.M., I. Syed, P.M. Moraes-Vieira, T. Zhang, M.A. Herman, E.A. Homan, R.T. Patel, J. Lee, S. Chen, O.D. Peroni, A.S. Dhaneshwar, A. Hammarstedt, U. Smith, T.E. McGraw, A. Saghatelian, and B.B. Kahn. (2014). Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell 159:318-32.

PubMed ID: 25303528

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