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商品描述
Overview
Nocodazoleisananti-mitoticagentthatreversIBLyinterfereswiththepolymerizationofmicrotubules(DeBrabanderetal.).Nocodazolebindstobeta-tubulinanddisruptsmicrotubuleassembly/disassemblydynamics,impairingformationofthemetaphasespindlesduringthecelldivisioncycle.ThispreventsmitosisbyinducingaG2/M-phasearrestandinducesapoptosisintumorcells(Jordanetal.).GENOMEEDITING·Synchronizeshumanpluripotentstemcells(hPSCs)intheG2/Mcellcyclephase,therebyincreasingtheefficiencyofhomology-directedrepair(HDR)inCRISPR-Cas9genomeediting(Linetal.;Yangetal.).CANCERRESEARCH·InducesapoptosisinleukemiccellswithoutharmingTcellsand/ormesenchymalstromalcellsthatwererecoveredfromthesamepatients(Frezzatoetal.).
AlternativeNames:
NSC238159;Oncodazole;R17934
CASNumber:
31430-18-9
ChemicalFormula:
C₁₄H₁₁N₃O₃S
MolecularWeight:
301.3g/mol
Purity:
≥98%
