Overview

iCell®MotorNeuronsKitincludescryopreservedmotorneuronsaswellasneuronalmediumandsupplements.Innervationofmusclefibersbyspinalmotorneuronsisessentialforcontrollingmusclecontractionandultimatelycoordinatedmovement.Neurodegenerativediseases,suchasALS(AmyotrophicLateralSclerosis‎)andSMA(SpinalMuscularAtrophy),arearesultoftheprogressivedegenerationofmotorneuronsthatleadstoanuncouplingofthisprocess.InordertoprovideresearcherswithamodelsystemforunderstandingbasicmotorneuronBIOLOGyandtodeveloptreatmentsforthesediseases,CDIoffersiCell®MotorNeurons.iCell®MotorNeuronsareahighlypurepopulationofhumanspinalmotorneuronsderivedfrominducedpluripotentstem(iPS)cellswiththefollowingfeatures:•Fullydifferentiated,≥87%(β-IIItubulin)purepopulationofprimarilycholinergichumanneurons(≥80%Isl1/2at14daysinvitro)•Displaytypicalneuronalmorphologywithbranchingneuritesandremainviableforanextendedcultureperiod(≥14days)•ExpressMarkerscharacteristicofmotorneurons•Availableincommercialquantities•Easytouse:SimplythawandplateThesecellsprovideareliablesourceofhumanneuronssuitableforusewithin:•Basicandtranslationalresearch:StudyingneurodegenerativediseaseslikeALS&SMA,myelination/demyelination,andneurogenesis•Drugdiscovery:FordiseasessuchasALSandSMA•Bioengineering:Developmentofneuromuscularjunctionmodels•Appliedmarkets:BoNTtesting•Toxicologyandsafetypharma:Fortestingchemicalwarfareagents,effectsofchemicalpesticides,etc.Certainproductsareonlyavailableinselectterritories.PleasecontactyourlocalSalesRepresentativeorProduct&ScientificSupportattechsupport@stemcell.comforfurtherinformation.