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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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商品描述
Overview
TheAA10antibodyreactswithbeta-tubulinIII,an~50-55kDastructuralproteinthatisaconstituentoftubulin.TubulinisthemajorcomponentofmicrotubuleswithintheCytoskeletonandisassembledfromheterodimersofalphaandbetatubulinsubunits.ThebetaIIIisoformoftubulin,alsoknownasneuron-specificclassIIIbeta-tubulin,isexpressedprimarilyinneuronsandiswidelyusedasaMarkertodistinguishneuronsfromothercelltypes.Beta-tubulinIIIcontributestomicrotubuleformationinneuronalcellbodiesandaxons,afunctioninvolvingGTPbinding,andplaysrolesinaxonaltransport,neuronalcellproliferation,anddifferentiation.Itishighlyexpressedinseveraltypesofcancerandisapredictiveandprognosticmarkerforvarioustumors,forexample,beingfoundinneoplasticbutnotinnormalglialcells.TheAA10antibodyisexpectedtorecognizeallmammalianhomologsofbeta-tubulinIII.
Subtype:
PrimaryAntibodies
TargetAntigen:
Beta-TubulinIII
AlternativeNames:
Class3beta-tubulin,classIIIbeta-tubulin,MC1R,neuron-specificclass3beta-tubulin,neuron-specificclassIIIbeta-tubulin,TUBB3,TUBB3,tubulinbeta3,tubulinbeta4,tubulinbetaIII
ReactiveSpecies:
Human;Mouse;Rat
Conjugation:
AlexaFluor488;Unconjugated
HostSpecies:
Mouse
CellType:
Neurons;NeuralCells,PSC-Derived
Application:
FlowCytometry;Immunocytochemistry;Immunofluorescence;Immunohistochemistry;Immunoprecipitation;WesternBlotting
AreaofInterest:
Neuroscience
Clone:
AA10
GeneID:
10381
Isotype:
IgG2a,kappa
