Productname451lLuBRViableCells(5x10^6cells)Catalognumber451lLuBR-01-0005-A(1ml)DescriptionBackground:451ILuBRisahumanmetastaticmelanomacellline.ThiscelllineisresistanttoBRAFandMEKinhibitors.ThiscelllinefeaturesthespecificV600E(Val600Glu)mutationatcodon600intheBRAFgene.ThismutationcausesconstitutivelyactivekinaseactivityandactivationofMEKandERKsignalingpathway.Thiscelllinewasderivedfromthesamepatientasthecelllines,WM164,and451Lu.451ILuBRcellsproducexenografttumorswheninjectedintoimmunocompromisedmice.ApplicationNote:Thekeyapplicationsofthesecelllinesincludegeneticstudies,xenograftproduction,drugtesting,anddrugtargetdiscovery.ThesecelllinemodelscanbeusedinvariousBIOLOGicalassays,andforidentifyingcriticaltargetgenes,andcellsignalingpathways.SourceRocklandProductcategoryCells,Media&FractionsProductsubcategoryCellLinesTargetspeciesHumanShipmentinfoDryIceNacresCodificationNA.81 Tebu-Bio通过我们广泛的完全可定制的服务,在体外模拟人体的生理环境。您指定的项目经理将帮助您定义最佳方法,以建立概念验证,发现和了解NCE和生物制剂的作用机理,获取具有相关生物标志物的证据...我们可以根据您不断变化的需求来处理您的全部或部分项目。所有CRO工作都是在我们通过ISO9001:2015和ISO14001:2015欧洲认证的实验室中秘密进行的,并且有明确但灵活的截止日期。无论您的研究领域是什么,通过外包到tebu-bio,您都可以节省时间和成本,同时确保您完全控制研究和知识产权。