- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
LATS1isaputativeserine/threoninekinasethatlocalizestothemitoticapparatusandcomplexeswithcellcyclecontrollerCDC2kinaseinearlymitosiswhichisphosphorylatedinacell-cycledependentmanner.TheN-terminalregionoftheproteinbindsCDC2toformacomplexshowingreducedH1histonekinaseactivitywhichindicatingaroleasanegativeregulatorofCDC2/cyclinAandtheC-terminalkinasedomainbindstoitsownN-terminalregion,suggestingpotentialnegativeregulationthroughinterferencewithcomplexformationviaintramolecularbinding(1).LATS1actasatumorsuppressorandplayanimportantroleinthedevelopmentofsoft-tissuesarcomas,ovarianstromalcelltumorsandahighsensitivitytocarcinogenictreatments(2).
GeneAliases:
WARTS;wts
GenbankNumber:
NM_004690
References:
1.Tao,W.et.al:HumanhomologueoftheDrosophilamelanogasterlatstumoursuppressormodulatesCDC2activity.NatureGenet.21:177-181,1999.2.St.John.et.al:MicedeficientofLats1developsoft-tissuesarcomas,ovariantumoursandpituitarydysfunction.NatureGenet.21:182-186,1999.
