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- Peptide Substrates
- Binding Proteins
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- 双加氧酶与蛋白质
- 脂质底物
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商品描述
Overview:
Rbistheretinoblastomageneproductandwasthefirsttumorsuppressorcloned.RbisanegativeregulatorofthecellcyclethroughitsABIlitytobindthetranscriptionfactorE2FandrepresstranscriptionofgenesrequiredforSphase(1).RbcanbindtoMDM2andthisovercomesboththeantiapoptoticfunctionofMDM2andtheMDM2-dependentdegradationofp53.RbassociateswiththePolycombgroup(PcG)proteinstoformarepressorcomplexthatblocksentryofcellsintomitosis(2).RbcolocalizeswithnuclearPcGcomplexesandisimportantforassociationofPcGcomplexeswithnucleartargets.
GeneAliases:
RB1,OSRC
GenbankNumber:
NM_000321
References:
1.Hanahan,D.etal:Thehallmarksofcancer.Cell100:57-70,2000.2.Dahiya,A.etal:LinkingtheRbandPolycombpathways.Molec.Cell8:557-568,2001.
