Overview:

EPHB2 is a member of the Eph family of receptor tyrosine kinases that mediate neuro-developmental processes such as boundary formation, axon guidance, vasculogenesis and cell migration. Activated EPHB2 regulates the activity of the non-receptor tyrosine kinase Abl (1). EPHB2 is overexpressed in a number of tumors, particularly glioblastoma. In fact, EPHB2 overexpression leads to increased glioma cell migration and invasion (2).

References:

1. Yu, H H. et al: Multiple signaling interation of Abl and Arg kinases with the EPhB2 receptor. Oncogene. 2001 Jul 5;20(30):3995-4006.2. Nakada, M. et al: The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells. Cancer Res. 2004 May 1;64(9):3179-85.3. Kalo, M S. et al: In vivo tyrosine phosphorylation sites of activated ephrin-B1 and ephB2 from neural tissue. J Biol Chem. 2001 Oct 19;276(42):38940-8.