- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
A naturally occurring polyether marine toxin. Potent and selective inhibitor of protein phosphatases inhibiting PP2A completely at 1nM and PP1 at higher concentrations, while PP2C is not inhibited. It is an extremely useful tool for studying cellular protein phosphorylation (2). Induces apoptosis in a variety of cell types (3). Activates atypical protein kinase isotypes and induces insulin-like effects in adipocytes (4).
References:
1. P Cohen et al. Trends Biochem. Sci.1990 15:98.2. DG Hardie et al.Methods Ezymol.1991 201:469.3. TJ Haneji et al. Int. J. Oncol. 2013 42:1904.4. ML Standaert et al.J. Biol. Chem. 1999 274:14074.