Overview:

TAR DNA binding protein (TARDBP) Human was originally discovered in a screen for transcriptional repressors of the transactive response (TAR) DNA binding element of the HIV-1 virus. Contain two RNA-recognition motifs (RRM1 and RRM2), one of which partially overlaps with a putative nuclear export sequence. Mutations in TARDBP were identified in amyotrophic lateral sclerosis (ALS) patients.

Gene Aliases:

ALS10; TARDBP

Genbank Number:

NM_007375

References:

1. Ou SH, et al: Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. J Virol 69:3584–3596. 19952. Gitcho MA, et al. TDP-43 A315T mutation in familial motor neuron disease. Ann Neurol 2008 63:535–538. 2008