Overview:

Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) is the receptor for TNFSD12/TWEAK and is the smallest member of the TNF receptor superfamily. It is composed of a signal peptide, an extracellular domain, a membrane-anchoring domain, and a cytoplasmic “death” domain, which can activate a cell’s apoptotic mechanisms. It also promotes endothelial cell proliferation and angiogenesis, and modulates cellular adhesion to matrix proteins. TNFRSF12A expression can be found in the spleen, thymus, small intestine, and colon, and can be activated by membrane-anchored or soluble versions of TWEAK.

Gene Aliases:

Fibroblast growth factor-inducible immediate-early response protein 14, Tweak-receptor, CD-antigen: CD266

Genbank Number:

Q9NP84