- 细胞因子
- Dihydropyrimidinase and Proteins
- Regulatory proteins
- 授予称号
- Peptide Substrates
- Isoform Specific Antibodies
- Deacetylase & Demethylase Proteins
- Acetyl & Methyltransferase Proteins
- siRNA Controls
- Cell Stress and Chaperone Proteins
- 激酶
- 双加氧酶与蛋白质
- Transcription Proteins
- Carbohydrate Kinases
- 表观遗传酶抑制剂
- Growth Factors
- 脂类激酶
- Phospholipase C and Proteins
- Mutant Kinases
- Oligo Substrates
- Fluorescent and Color Proteins
Overview:
Tau-441orTau-FisamemberoftheTaufamilyofproteinswhichfunctiontostABIlizethemicrotubulesbybindingtothem.TauproteinsaresubjecttophosphorylationandthisphenomenonregulatestheassociationoftheTauproteinwiththemicrotubules(1).DepositsofAlzheimer"sdiseaseAD-associatedproteins,suchashyperphosphorylatedTau,aswellasothersharedmisfoldedproteins,suchas,β-amyloidprecursorprotein(βAPP),ubiquitin,andvariouschaperonesandproteinkinasesarethoughttoplayapathologicroleinthecognitivedeclineandmuscularfailure.MalfunctioningofTauproteinsisassociatedwithmicrotubulesdisintegrationandcollapsingoftheneuronaltransportsystem(2).
GeneAliases:
Tau-F,(N2R4),Tau-4,MAPT,MSTD,PPND,DDPAC,MAPTL,MTBT1,MTBT2,FTDP-17,FLJ31424,MGC138549
GenbankNumber:
P10636-8
References:
1.Zilka,N.,etal.TruncatedtaufromsporADIcAlzheimer"sdiseasesufficestodriveneurofibrillarydegenerationinvivo.FEBSLett.2006;508:3582-3588.2.Rial,A.etal:CalciumDyshomeostasisinβ-AmyloidandTau-bearingSkeletalMyotubes.J.Biol.Chem.,2004;279:3524-53532.
