- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
PP2Bisakeyregulatoroftheanaphase-promotingfactorwhichisanexcellentsubstrateforproteinphosphatase.PP2Bisinvolvedinbovineoculartissuesandispostulatedtobeinvolvedintheimmunologicprivilegeofthecornea,inretinalsignaltransduction,andinthetoxiceffectsofimmunosuppressantsontheeye.PP2BactsasaninhibitoryconstraintonI-LTPthatisrelievedbyPKA,andthatthisinhibitoryconstraintactsasagatetoregulatethesynapticinductionofL-LTP(1).PP2Bplaysaroleinthetransitionfromshort-tolong-termmemoryandalsoregulatesboneformationthroughaneffectonosteoblastdifferentiation(2).
GeneAliases:
PPP2B,PPP3CA,CALN,CCN1,CNA1,CALNA,CALNA1
GenbankNumber:
NM_001130691
References:
1.Winder.et.al:Geneticandpharmacologicalevidenceforanovel,intermediatephaseoflong-termpotentiationsuppressedbycalcineurin.Cell92:25-37,1998.2.Sun,L.et.al:Calcineurinregulatesboneformationbytheosteoblast.Proc.Nat.Acad.Sci.102:17130-17135,2005.
