- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
PORisaflavoproteinthatdonateselectronstoallmicrosomalP450enzymes,includingthesteroidogenicenzymesP450c17,P450c21,andCYP51A1.PORencodesanendoplasmicreticulummembraneoxidoreductasewithanFAD-bindingdomainandaflavodoxin-likedomainwhichbindstwocofactors,FADandFMN,whichallowittodonateelectronsdirectlyfromNADPHtoallmicrosomalP450enzymes(1).PORhasbeenlinkedwithvariousdiseases,includingapparentcombinedP450C17andP450C21deficiency,amenorrheaanddisorderedsteroidogenesis,congenitaladrenalhyperplasiaandAntley-Bixlersyndrome(2).
GeneAliases:
CYPOR
GenbankNumber:
BC034277
References:
1.Shephard,E.A.et.al:IsolationofahumancytochromeP-450reductaseCDNAcloneandlocalizationofthecorrespondinggenetochromosome7q11.2.Ann.Hum.Genet.53:291-301,1989.2.Peterson,R.E.et.al:Malepseudohermaphroditismduetomultipledefectsinsteroid-biosyntheticmicrosomalmixed-functionoxidases:anewvariantofcongenitaladrenalhyperplasia.NewEng.J.Med.313:1182-1191,1985.
