- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
NPR1ornatriureticpeptidereceptor1isamembrane-boundguanylatecyclasethatservesasthereceptorforbothatrialandbrainnatriureticpeptides(1).NPR1expressioninfluencesbloodpressuresofmiceinadose-dependentmanner.ANPandNPR1bindinginducesanincreaseinintracellularcGMPwhichinitiatesnatriuresis,diuresis,andvasodilation,allofwhichcontributetoloweringbloodpressure.LowNpr1expressionleadstoasalt-sensitiveincreaseinBP,whereashighNpr1expressionlowersBPandprotectsagainsthighdietarysalt(2).
GeneAliases:
ANPa,GUC2A,GUCY2A
GenbankNumber:
BC063304
References:
1.Garbers,D.L.et.al:Guanylylcyclasereceptors.J.Biol.Chem.269:30741-30744,1994.2.Oliver,P.M.et.al:Natriureticpeptidereceptor1expressioninfluencesbloodpressuresofmiceinadose-dependentmanner.Proc.Nat.Acad.Sci.95:2547-2551,1998.
