- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
IKKgammaisaserine/threonineproteinkinasethatphosphorylatestheI-kappa-BproteinwhichisaninhibitorofthetranscriptionfactorNF-kappa-Bcomplex.PhosphorylationofI-kappa-Bproteintriggersthedegradationoftheinhibitorviatheubiquitinationpathway,therebyactivatingNF-kappa-Bcomplex.IKKgammaformsdimersandtrimersandinteractspreferentiallywithIKKbetabutnotIKKalpha(1).IKKgammaassociateswithactivatedATMaftertheinductionofDNAdouble-strandbreaks(2).ATMphosphorylatesserine-85ofIKKgammatopromoteitsubiquitin-dependentnuclearexport.
GeneAliases:
IKBKG;AMCBX1;FIP-3;FIP3;Fip3p;IKK-gamma;IP;IP1;IP2;IPD2;NEMO
GenbankNumber:
NM_003639
References:
1.Rothwarf,D.M.etal:IKK-gammaisanessentialregulatorysubunitoftheI-kappa-Bkinasecomplex.Nature395:297-300,1998.2.Wu,Z-H.etal:MolecularlinkagebetweenthekinaseATMandNF-kappaBsignalinginresponsetogenotoxicstimuli.Science311:1141-1146,2006.
