- 细胞因子
- Dihydropyrimidinase and Proteins
- Regulatory proteins
- 授予称号
- Peptide Substrates
- Isoform Specific Antibodies
- Deacetylase & Demethylase Proteins
- Acetyl & Methyltransferase Proteins
- siRNA Controls
- Cell Stress and Chaperone Proteins
- 激酶
- 双加氧酶与蛋白质
- Transcription Proteins
- Carbohydrate Kinases
- 表观遗传酶抑制剂
- Growth Factors
- 脂类激酶
- Phospholipase C and Proteins
- Mutant Kinases
- Oligo Substrates
- Fluorescent and Color Proteins
Overview:
STK19isamemberoftheserine/threoninekinasefamilythatshowsamanganese-dependentproteinkinaseactivityandphosphorylatesα-caseinatser/thrresiduesandhistoneatserresidues.STK19containsapositivelychargedputativenuclearlocalizationsignal,multiplepotentialphosphorylationsites,2amidationsites,9potentialN-myristoylationsites,andnoN-glycosylationsites.STK19hasbeenshowntolocalizepredominantlyinthenucleus(1).ThephosphorylationofSTK19isthoughttobeinvolvedintranscriptionalregulation.STK19localizestothemajorhistocompatibilitycomplex(MHC)classIIIregiononchromosome6(2).
GeneAliases:
D6S60;D6S60E;G11;HLA-RP1;RP1
GenbankNumber:
NM_004197
References:
1.Gomez-Escobar,N.et.al:TheG11genelocatedinthemajorhistocompatibilitycomplexencodesanovelnuclearserine/threonineproteinkinase.J.Biol.Chem.273:30954-30960,1998.2.Shen,L.et.al:StructureandgeneticsofthepartiallyduplicatedgeneRPlocatedimmediatelyupstreamofthecomplementC4AandtheC4BgenesintheHLAclassIIIregion:molecularcloning,exon-intronstructure,compositeretroposon,andbreakpointgeneduplication.J.Biol.Chem.269:8466-8476,1994.
