- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
SGK3isamemberoftheSGKfamilyandencodesaphosphoproteinwithaPX(phoxhomology)domain.PKD1canphosphorylateandactivateSGK3invitro(1).A10-foldincreaseinPKD1increasesthephosphorylationstatusofSGK3.Whenexpressedinhumanembryonickidneycells,IGF1andperoxidesignificantlyactivateSGK3,andtheactivationcouldbereducedbypreincubationwithinhibitorsofPI3kinase.Ayeast2-hybridscreenfounddirectinteractionbetweenhumanSGK3andGSK3β.SGK3phosphorylatesseveraltargetproteinsandhasaroleinneutralaminoacidtransportandactivationofpotassiumandchloridechannels(2).
GeneAliases:
CISK,SGKL
GenbankNumber:
NM_013257
References:
1.Kobayashi,T.etal:Characterizationofthestructureandregulationoftwonovelisoformsofserum-andglucocorticoid-inducedproteinkinase.Biochem.J.344:189-197,1999.2.Gamper,N.etal:K+channelactivationbyallthreeisoformsofserum-andglucocorticoid-dependentproteinkinaseSGK.Europ.J.Physiol.445:60-66,2002.
