- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
SGK1isamemberoftheserum-andglucocorticoid-inducedproteinkinasethatisactivatedinvitroby3-phosphoinositide-dependentproteinkinase-1(PDK1)andinvivoinresponsetosignalsthatactivatephosphatidylinositol(PI)3-kinase(1).SGK1mRNAisexpressedinalltissuesandthelevelofSGK1mRNAisincreasedbystimulationwithserumordexamethasone.SGK1promotescellsurvivalbyphosphorylatingandinactivatingFKHRL1(2).SGKandAktdisplaydifferenceswithrespecttotheefficacywithwhichtheyphosphorylatethethreeregulatorysitesonFKHRL1.
GeneAliases:
SGK
GenbankNumber:
NM_005627
References:
1.Kobayashii,T.etal:Characterizationofthestructureandregulationoftwonovelisoformsofserum-andglucocorticoid-inducedproteinkinase.BiochemJ.1999Nov15;344Pt1:189-97.2.Brunet,A.etal:ProteinkinaseSGKmediatessurvivalsignalsbyphosphorylatingtheforkheadtranscriptionfactorFKHRL1(FOXO3a).MolCellBiol.2001Feb;21(3):952-65.
