- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
c-KITisaproto-oncogeneandatype3transmembranereceptorforMGF(mastcellgrowthfactor,alsoknownasstemcellfactor).c-KITwasfirstidentifiedasthecellularhomologofthefelinesarcomaviraloncogenev-kit.c-KITtogetherwithitsligandregulatesgrowthandactivationofavarietyofhemopoieticandnon-hemopoieticcells.Mutationsinc-KITareassociatedwithgastrointestinalstromaltumors,mastcelldisease,acutemyelogenouslukemia,andpiebaldism.Recently,deregulationoftheKITreceptorTKbytheprevalentactivationloopmutationD816Vhasservedasafocalpointintherapeuticstrategiesaimedatcurbingneoplasticmastcellgrowth(2).
GeneAliases:
PBT,SCFR,CD117
GenbankNumber:
NM_000222
References:
1.Berger,SA.:SignalingpathwaysinfluencingSLFandc-kit-mediatedsurvivalandproliferation.ImmunolRes.2006;35(1-2):1-12.2.Gotlib,J.:KITmutationsinmastocytosisandtheirpotentialastherapeutictargets.ImmunolAllergyClinNorthAm.2006Aug;26(3):575-92.
