- 细胞因子
- Dihydropyrimidinase and Proteins
- Regulatory proteins
- 授予称号
- Peptide Substrates
- Isoform Specific Antibodies
- Deacetylase & Demethylase Proteins
- Acetyl & Methyltransferase Proteins
- siRNA Controls
- Cell Stress and Chaperone Proteins
- 激酶
- 双加氧酶与蛋白质
- Transcription Proteins
- Carbohydrate Kinases
- 表观遗传酶抑制剂
- Growth Factors
- 脂类激酶
- Phospholipase C and Proteins
- Mutant Kinases
- Oligo Substrates
- Fluorescent and Color Proteins
Overview:
c-KITisaproto-oncogeneandatype3transmembranereceptorforMGF(mastcellgrowthfactor,alsoknownasstemcellfactor).c-KITwasfirstidentifiedasthecellularhomologofthefelinesarcomaviraloncogenev-kit.c-KITtogetherwithitsligandregulatesgrowthandactivationofavarietyofhemopoieticandnon-hemopoieticcells.Mutationsinc-KITareassociatedwithgastrointestinalstromaltumors,mastcelldisease,acutemyelogenouslukemia,andpiebaldism.Recently,deregulationoftheKITreceptorTKbytheprevalentactivationloopmutationD816Vhasservedasafocalpointintherapeuticstrategiesaimedatcurbingneoplasticmastcellgrowth(2).
GeneAliases:
PBT,SCFR,CD117
GenbankNumber:
NM_000222
References:
1.Berger,SA.:SignalingpathwaysinfluencingSLFandc-kit-mediatedsurvivalandproliferation.ImmunolRes.2006;35(1-2):1-12.2.Gotlib,J.:KITmutationsinmastocytosisandtheirpotentialastherapeutictargets.ImmunolAllergyClinNorthAm.2006Aug;26(3):575-92.
