- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
DMPK(orMyotonicDystrophyProteinKinase)isaserine-threoninekinasethatiscloselyrelatedtootherkinasesthatinteractwithmembersoftheRhofamilyofsmallGTPases.DMPKproteinhasaleucine-richdomainattheN-terminus,aserine/threoninekinasedomaininthemiddle,andahydrophobicregionattheC-terminus.TheN-terminusofDMPKplaysanimportantroleinDMPKkinaseactivity,andtheC-terminusofDMPKdeterminestheintracellularlocalizationoftheprotein(1).Myotonicdystrophytype1isanautosomaldominantdiseasecausedbyatrinucleotiderepeat-expansion,cytosine-thymine-guanine(CTG)n,inthe3"untranslatedregionofDMPK(2).
GeneAliases:
DM,DM1,DMK,MDPK,DM1PK,MT-PK
GenbankNumber:
NM_004409
References:
1.Sasagawa,N.etal:OverexpressionofhumanmyotonicdystrophyproteinkinaseinSchizosaccharomycespombeinducesanabnormalpolarizedandswollencellmorphology.JBiochem.2003Oct;134(4):537-42.2.Salvatori,S.etal:DecreasedexpressionofDMPK:correlationwithCTGrepeatexpansionandfibretypecompositioninmyotonicdystrophytype1.NeurolSci.2005Oct;26(4):235-42.
