- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
PTEN(phosphataseandtensinhomolog)isatumorsuppressorthatisfrequentlymutatedinalargenumberofcancers(1).PTENhasphosphatidylinositol-3,4,5-trisphosphate3-phosphataseactivityandcontainsatensinlikedomainaswellasacatalyticdomainsimilartothatofthedualspecificityproteintyrosinephosphatases.Unlikemostoftheproteintyrosinephosphatases,PTENpreferentiallydephosphorylatesphosphoinositidesubstratesandisresponsIBLefornegativelyregulatingtheintracellularlevelsofphosphatidylinositol-3,4,5-trisphosphateincells.PTENfunctionsasatumorsuppressorbynegativelyregulatingthePI3K/AKTsignalingpathway(2).
GeneAliases:
BZS,MHAM,TEP1,MMAC1,PTEN1,MGC11227
GenbankNumber:
NM_000314
References:
1.Butler,M.G.etal:SubsetofindividualswithautismspectrumdisordersandextrememacrocephalyassociatedwithgermlinePTENtumoursuppressorgenemutations.J.Med.Genet.2005;42(4):318-21.2.Steck,P.A.etaal:Identificationofacandidatetumoursuppressorgene,MMAC1,atchromosome10q23.3thatismutatedinmultipleadvancedcancers.Nat.Genet.1997;15(4):356-62
