- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
NPR1 or natriuretic peptide receptor 1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (1). NPR1 expression influences blood pressures of mice in a dose-dependent manner. ANP and NPR1 binding induces an increase in intracellular cGMP which initiates natriuresis, diuresis, and vasodilation, all of which contribute to lowering blood pressure. Low Npr1 expression leads to a salt-sensitive increase in BP, whereas high Npr1 expression lowers BP and protects against high dietary salt (2).
Gene Aliases:
ANPa, GUC2A, GUCY2A
Genbank Number:
BC063304
References:
1. Garbers, D. L.et.al: Guanylyl cyclase receptors. J. Biol. Chem. 269: 30741-30744, 1994.2. Oliver, P. M.et.al: Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner. Proc. Nat. Acad. Sci. 95: 2547-2551, 1998.
