- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
The mammalian target of rapamycin, mTOR, also known as FRAP or RAFT, is a Ser/Thr protein kinase. mTOR acts as a sensor for ATP and amino acids, balancing the availability of nutrients and cell growth (1). When sufficient nutrients are available, mTOR responds to a phosphatidic acid-mediated signal, transmits a positive signal to p70 S6 kinase and participates in the inactivation of the eIF4E inhibitor, 4E-BP1 (2).
References:
1. Sabers CJ et al: Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem. 270(2): 815-22, 1995.2. Fang Y. et al: Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science. 294(5548): 1942-5, 2001.3. Holz MK, et,al. (2005) J Biol Chem ;280:26089-26093.4. Chiang GG, et,al. (2005) J Biol Chem ;280: 25485-25490.5. Mothe-Satney I, et,al. (2004) J Biol Chem ;279: 42628-42637.6. Bolster DR, et,al. (2003) J Physiol ;553:213-220.
