Overview:

The RSK or 90-kDa ribosomal S6 kinase family of proteins isa group of highly conserved Ser/Thr kinases that regulatediverse cellular processes during the growth factor mediatedstimulation of cell proliferation, survival anddifferentiation (1). In mammals, four RSK genes havebeen identified (RSK1, RSK2, RSK3 and RSK4), and the RSKisoforms are composed of two distinct and functionalkinase domains that are activated in a sequentialmanner by a series of phosphorylation events. RSKs aredownstream effectors of the Ras-extracellular signal regulatedkinase (ERK) / mitogen-activated protein kinase(MAPK) signalling cascade.

References:

1. Anjum R. et al:The RSK family of kinases: emerging roles incellular signalling.Nat Rev Mol Cell Biol. 2008 Oct;9(10):747-58.