- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
TheRaspathwayisacriticalsignaltransductioncascadethatregulatescellularproliferation,differentiation,survival,andoncogenictransformation.TheRasfamilyofmembraneassociatedGTPasesdirectlybindsRAF1,itsdirectdownstreameffector(1).ActivatedRAF1phosphorylatesthedualspecificityproteinkinasesMEK1andMEK2,whichinturnphosphorylatethedownstreamserine/threoninespecificproteinkinasesERK1andERK2.ActivatedERKsarepleiotropiceffectorsofcellphysiologyandplayanimportantroleinthecontrolofgeneexpressioninvolvedinthecelldivisioncycle,apoptosis,celldifferentiationandcellmigration(2).DownregulationofRAF1isregulatedbyphosphorylationatSer301andSer642(3).
References:
1.Rapp,U.etal:StructureandBIOLOGicalactivityofv-raf,auniqueoncogenetransducedbyaretrovirus.Proc.Nat.Acad.Sci.80:4218-4222,1983.2.Li,P.etal:Raf-1:akinasecurrentlywithoutacausebutnotlackingineffects.Cell64:479-482,1991.3.DoughertyM.K.etal:RegulationofRaf-1byDirectFeedbackPhosphorylation.MolCell17:215-224,2005.
