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- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
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商品描述
Overview:
TheParkinproteinisacomponentoftheE3ubiquitinligasecomplex,whichisresponsIBLefortargetingofproteinsfordegradation.HereditaryParkinson’sdiseaseismostcommonlycausedbymutationsintheparkingene.ThediseaseischaracterizedbytheprogressivelossofdopaminergicneuronsandthepresenceofLewybodiesinthesubstanianigra(1).RecentstudiesindicatethatphosphorylationofParkinatSer101andSer378mightbeimportantforregulatingE3ubiquitinligaseactivity(2).
References:
1.JennerP.etal:OxidativestressasacauseofnigralcelldeathinParkinson’sdiseaseandincidentalLewybodydisease.AnnNeurol.32Suppl:S82-7,1992.2.YamamotoA.etal:ParkinphosphorylationandmodulationofitsE#ubiquitinligaseactivity.JBiolChem.280(5):3390-9,2005.
