- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
Glycogensynthasekinase3(GSK3)isaserine/threoninekinasethatisinvolvedintheregulationofmanysignalingpathways.Therehavebeentwoisoformsidentified,GSK3alphaandGSK3beta.GSK3betaisubiquitouslyexpressedinhumantissuesandisimplicatedinregulatingseveralphysiologicalprocesses.Theseincludethecontrolofglycogen,proteinsynthesisbyinsulinandmodulationofthetranscriptionfactorsAP-1andCREB.GSK3betahasbeenshowntoplayakeyinhibitoryroleinboththeinsulinandWntsignalingpathways(1).GSK3betaisinhibitedbyphosphorylationatSer9.InsulinsignalingislargelyresponsIBLeforthismodeofGSK3betainhibition(2).
References:
1.Papkoff,J.etal:WNT-1andHGFregulateGSK3bactivityandbetacateninsignalinginmammaryepithelialcells.BiochemBiophysResCommun.1998Jun29;247(3):851-8.2.Sutherland,C.etal:Inactivationofglycogensynthasekinase3betabyphosphorylation:newkinaseconnectionsininsulinandgrowthfactorsignaling.BiochemJ.1993Nov15;296(Pt.1):15-9.
