- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
Theepidermalgrowthfactorreceptor(EGFR)isatransmembranetyrosinekinase.KnownligandsofEGFRincludeEGF,TGFA/TGF-alpha,amphiregulin,epigen/EPGN,BTC/betacellulin,epiregulin/EREGandHBEGF/heparin-bindingEGF.Ligandbindinginducesreceptorhomo-andhetero-dimerizationandtyrosineautophosphorylation,whichtriggersdownstreamsignalingevents.TheconsequencesofEFGRsignalingincludecellproliferation,differentiation,motility,andcellsurvival(1).ActivationofEGFRtriggersmitogenicsignalingingastrointestinalmucosaandEGFRupregulatedincoloncancersandmostneoplasms(2).EGFRstimulationalsoactivatestheERK-signalingpathwayinnormalgastricepithelialandcoloncancercelllines.Incontrast,selectiveinhibitionofEGFRsignificantlyreducesERK2activation,c-fosmRNAexpressionandcellproliferation.MutationsinEGFRarealsoimplicatedinspecificformsoflungcancer.
References:
1.WangK,etal:Epidermalgrowthfactorreceptor-deficientmicehavedelayedprimaryendochondralossificationbecauseofdefectiveosteoclastrecruitment.J.Biol.Chem.279:53848-53856,2004.2.KobayashiS,etal:EGFRmutationandresistanceofnon-small-celllungcancertogefitinib.NewEng.J.Med.352:786-792,2005.
