- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
Beta-cateninsareubiquitouslyexpressedcytoplasmicproteins.TheyassociatewithE-cadherinandthusrepresentcentralcomponentsofthecadherincelladhesioncomplex(1).beta-catenininteractswithTCFandLEFtranscriptionfactorsandareessentialforneuraldevelopmentintheWingless/Wntsignalingpathway(2).Theadenomatouspolyposiscoli(APC)tumor-suppressorprotein,togetherwithAxinandGSK3beta,formaWnt-regulatedsignalingcomplexthatmediatesphosphorylationdependentdegradationofbeta-cateninbytheproteasome.Specifically,beta-cateninisregulatedbysequentialphosphorylationofSer29,Ser33,Ser37andThr41byglycogensynthasekinase3beta(GSK3beta)(Liuetal.2002).Thishyperphosphorylationpromotestheubiquitylationandtargeteddegradationofbeta-catenin.Mutationsincomponentsofthisphosphorylationregulatedprocessthatpreventbeta-cateninhyperphosphorylationbyGSK3betaareassociatedwithcancers(4).
References:
1.Morin,PJ.etal:Activationofbeta-catenen-Tcfsignalingincoloncancerbymutationsinbeta-cateninorAPC.Science1997;275(5307):1787-1790.2.Ding,Y.etal:Wntsignaltransduction:kinasecogsinanano-machine?TrendsBiochemSci2002;27:327-329.3.Liu,C.etal:Controlofbeta-cateninphosphorylation/degradationbyadual-kinasemechanism.Cell2003108:837-847.4.Wang,ZH.etal:Phosphorylationofbeta-cateninatS33,S37,orT41canoccurintheabsenceofphosphorylationatT45incoloncancercells.2003CancerRes200363:5234-5235.
