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商品描述
Overview:
AKT1/PKBαisaserine/threoninekinasethatbelongstotheAKTfamily.AKT1isactivatedincellsinresponsetodiversestimulisuchashormones,growthfactorsandextracellularmatrixcomponentsandisinvolvedinglucosemetabolism,transcription,survival,cellproliferation,angiogenesis,andcellmotility(1).AKT1isfrequentlyoverexpressedandactiveinmanytypesofhumancancersincludingcancersofcolon,breast,brain,pancreasandprostateaswellaslymphomasandleukemias(2).
References:
1.Coffer,PJ.etal:ProteinkinaseB(c-Akt):amultifunctionalmediatorofphosphatidylinositol3-kinaseactivation.BiochemJ.1998Oct1;335(Pt1):1-13. 2.Anderson,KE.etal:TranslocationofPDK-1totheplasmamembraneisimportantinallowingPDK-1toactivateproteinkinaseB.CurrBiol.1998Jun4;8(12):684-91.
