Product overview

• NameReserpine
• Short descriptionVesicular monoamine re-uptake blocker
• Biological descriptionVesicular monoamine re-uptake blocker. Irreversibly binds VMAT2 to deplete synaptic monoamines. Produces depression-like effects and shows antipsychotic and antihypertensive effects.
• Biological actionBlocker
• Purity>99%
• Our products in actionSubmit Your Citation Now

Properties

• Chemical name(3β,16β,17α,18β,20α)-11,17-Dimethoxy-18- [(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxyl ic acid methyl ester
• Molecular Weight608.68
• Chemical structure
• Molecular FormulaC₃₃H₄₀N₂O₉
• CAS Number50-55-5
• PubChem identifier5770
• SMILESCO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C([C@H]3C[C@@H]2[C@@H]1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC
• InChiInChI=1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
• InChiKeyQEVHRUUCFGRFIF-MDEJGZGSSA-N
• MDL numberMFCD00005091

Storing and Using Your Product

• Storage instructionsRoom temperature
• Solubility overviewSoluble in DMSO (10 mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Reserpine

• Radioligands of the vesicular monoamine transporter and their use as markers of monoamine storage vesicles.

  Henry JP et al (1989)Biochem Pharmacol 38(15) : 2395-404. PubMedID: 2667522

• Reserpine binding to a vesicular amine transporter expressed in Chinese hamster ovary fibroblasts.

  Schuldiner S et al (1993)J Biol Chem 268(1) : 29-34. PubMedID: 8416935

• Antidepressant-like effect of tetrahydroisoquinoline amines in the animal model of depressive disorder induced by repeated administration of a low dose of reserpine: behavioral and neurochemical studies in the rat.

  Antkiewicz-Michaluk L et al (2014)Neurotox Res 26(1) : 85-98. PubMedID: 24407488

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