动脉粥样硬化（atherosclerosis，AS）是冠心病、脑梗死、外周血管病的主要原因。脂质代谢障碍为动脉粥样硬化的病变基础，其特点是受累动脉病变从内膜开始，一般先有脂质和复合糖类积聚、出血及血栓形成，进而纤维组织增生及钙质沉着，并有动脉中层的逐渐蜕变和钙化，导致动脉壁增厚变硬、血管腔狭窄。病变常累及大中肌性动脉，一旦发展到足以阻塞动脉腔，则该动脉所供应的组织或器官将缺血或坏死。由于在动脉内膜积聚的脂质外观呈黄色粥样，因此称为动脉粥样硬化。

Figure A shows a normal artery with normal blood flow. The inset image shows a cross-section of a normal artery. Figure B shows an artery with plaque buildup.

Novus提供动脉粥样硬化研究相关产品，部分热销产品列表如下：

产品引用文献

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2. [SR-BII Antibody NB400-102] Kushiyama A, et al. Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):291-8.[PMID: 22095983]

3. [SR-BI Antibody NB400-104] Molina-Jimenez F, Benedicto I, Dao Thi VL, et al. Matrigel-embedded 3D culture of Huh-7 cells as a hepatocyte-like polarized system to study hepatitis C virus cycle. Virology. 2012 Jan 24.[PMID: 22280897]

4. [SR-BI Antibody NB400-104] Storey SM, McIntosh AL, Huang H, et al. Intracellular Cholesterol Binding Proteins Enhance HDL-mediated Cholesterol Uptake in Cultured Primary Mouse Hepatocytes. American Journal of Physiology. Gastrointestinal and Liver Physiology. 2012 Jan 12. [PMID: 22241858]

5. [SR-BI Antibody NB400-113] Kim K-Y, Stevens MV, Akter MH, et al. Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells. J Clin Invest. 2011 Aug 25. [PMID: 21865652]

6. [SR-BI/SR-BII Antibody NB400-134] Hu J, Zhang Z, Shen W-J, et al. Differential Roles of Cysteine Residues inCellular Trafficking, Dimerization, and Function of the HDL Receptor, SR-BI. Biochemistry. 2011 Nov 18.[PMID: 22097902]

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