Description

Zymosan is a yeast cell wall derivative that is composed of b-glucans, mannans, mannoproteins and chitin. Zymosan is a known activator of TLR2, of which inflammatory responses to this particle are synergistically generated by collaboration with Dectin-1 and result in NF-kB-induced inflammatory cytokine production and phagocytosis1. Zymosan is also known to directly bind TLR2. Product Validation The data shows that Zymosan activated the TLR2 cells but not the control cells.

Application Notes

This product is useful for Activation of Toll-like Receptor 2 (TLR2).Stimulation of TLR2 has been reported with 1-10 ug/ml. Note: TLR2 activation at this range of concentrations of Zymosan has also been observed in our product validation tests, please see the image. Use in In vivo assay and Functional inhibition reported in scientific literature (PMID 25846753). Use in Ligand activation reported in scientific literature (PMID 25957979). Use in In vitro reported in scientific literature (PMID 27351455).

Publications

ReadPublications using NBP2-26233 in the following applications: Func 3 publications In vitro 2 publications In-vivo 1 publication LA 1 publication

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